Rev Bras Oftalmol.2026;85:e0020
Carta para: Crosslinking de colágeno corneano por exposição solar e riboflavina oral em altas doses: um estudo observacional longitudinal multicêntrico
DOI: 10.37039/1982.8551.20260020
STUDY DESIGN LIMITATIONS
The authors report a retrospective, uncontrolled, multicenter series of 53 patients, with attrition to 42 patients after only 6 months. The absence of a control group or blinding means that natural variability, regression to the mean, or periods of spontaneous stability cannot be excluded as explanations for their findings. The authors acknowledge that “the absence of a control group and blinding, as well as the relatively small number of individuals followed, can be mentioned”.
Furthermore, the inclusion criteria did not specify progressive keratoconus. Stabilization in eyes that may not have been progressing at baseline cannot be interpreted as a therapeutic effect. This omission further limits the validity of the conclusions.
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