PURPOSE: Evaluate the results and complications from type A botulinum toxin for strabismus treatment. METHODS: Type A botulinum toxin (Prosigne®) was used in 20 patients from Faculdade de Medicina do ABC (FMABC) ophthalmology ambulatory from 2006 to 2009, for esotropia treatment. The application was performed in 15 children with esotropia smaller than 50 prism diopter (PD) in both medial rectus muscles, and in 5 adults with esotropia due to VI nerve paralysis or paresis, only in the opposite muscle. The […]

PURPOSE: To evaluate the measurement of palpebral fissure in patients with facial dystonias before and after periocular injection with botulinum toxin type A. METHODS: We studied patients with benign essential blepharospasm and hemifacial spasm underwent periocular injection of botulinum toxin type A by the inner orbital technique of application. Patients were photographed 14 days before and after application. The palpebral fissure was measured in these images by means of computerized image processing using the program ImageJ. The palpebral fissure changes […]

PURPOSE: To determine the corneal keratometric variation in patients’ eyes with unilateral hemifacial spasm which underwent treatment with botulinum toxin and set against control group. METHODS: Eighteen patients with hemifacial spasm were submitted to complete ophthalmologic exam, corneal topography and Orbscan previously botulinum toxin application and one month afterwards. They were evaluated for keratometry, BFS (anterior and posterior) and Roush value. RESULTS: There were no statistical differences between eyes with hemi facial spasm and normal eyes related to keratometric values […]

PURPOSE: To investigate the efficacy of EMLA® (EMLA) cream for pain relief before periocular botulinum toxin injection (BTX) on the treatment of essential benign blepharospasm (BEB). METHODS: In this prospective study, 13 patients given bilateral periocular botulinum injections for blepharospasm treatment were included. Prior to the injections, EMLA cream was applied to the right periocular side and placebo to the left side. Relative pain score from 0 to 10 was recorded after the procedure. RESULTS: The average pain score on […]

PURPOSE: To evaluate the effect of botulinum toxin A and crotoxin on satellite cell activation in the muscle fibers of superior rectus muscles of rabbits. METHODS: The superior rectus muscles in the right eyes of 29 male, albino, New Zealand rabbits were inoculated with different doses of botulinum toxin A or crotoxin. The contra-lateral superior rectus muscles in each rabbit were inoculated with the same volume of saline solution only. The animals were sacrificed either 12, 18 or 25 days […]