PURPOSE: The present work aimed to present the development of a conjunctival mucosa system for the controlled delivery of cyclosporine A (CsA) in the treatment of keratoconjunctivitis sicca (KCS). METHODS: The conjunctival mucosa system was prepared in the form of films containing chitosan as the polymer and CsA as the drug (25%w/v). The films were applied to the conjunctival sac of one eye from normal rabbits (n=6), and the evaluation of lachrymal production was performed daily, before and after application, […]
