ABSTRACT Objective: Embryonic exposure to valproic acid is a widely used model for the study of neurodevelopmental disorders such as autism spectrum disorders. In zebrafish, early exposure to valproic acid results in the major behavioral, neurological, and genetic phenotypes of this disorder. Autism spectrum disorders have several associated symptoms, such as changes in sensory processing, sleep problems, and hyper- or hyposensitivity to light. This work investigates the hypothesis of changes at the retinal level due to embryonic exposure to valproic […]

ABSTRACT Purpose: To describe an innovative animal model of eye transplantation used in rabbits. Methods: six Dutch-belted male rabbits were submitted to lateral orbitotomy in the right eye, wide retrobulbar anatomy exposure, dissection of the structures, identification and distal section of the optic nerve followed by anastomosis either by vicryl (group 1) or fibrin glue (group 2). Electroretinography recording was performed before the section of the optic nerve and every 30 seconds after, to monitor the function of retina. Left […]

Purpose: Describe an animal model of dry induced by topical instillation of BAK and evaluate ocular surface biomarkers and histological findings. Methods: Male Wistar rats were used.Topical instillation of 0.2% BAK eyedrops twice a day during 7 days, in the right eye of each animal, while the other eye was taken as control. After 7 days treatment, we performed evaluation of tear film osmolarity, the red phenol thread and ocular surface staining with fluorescein and lissamine green. Afterwards, the animals […]