ABSTRACT Objective: To assess the diagnostic accuracy of ChatGPT in analyzing OCT images. Methods: A total of 300 OCT images, previously interpreted by specialists, were analyzed by ChatGPT under three scenarios: image-only input; input with additional epidemiological data; and input with detailed clinical data. Sensitivity, specificity, and accuracy rates were compared across scenarios using appropriate statistical analyses (p < 0.05). Results: Overall accuracy was 66.33% in the image-only scenario, 82.33% with epidemiological data, and 92.67% with clinical data. Sensitivity for [...]