ABSTRACT Non-infectious uveitis is a major cause of visual loss, particularly among working-age adults. It is an intraocular inflammatory condition mediated by autoreactive T lymphocytes, and its severe forms may require therapies beyond corticosteroids. This article reviews recent advances in the treatment of the disease, emphasizing natural compounds and innovative ocular drug delivery systems, particularly those based on pharmaceutical nanotechnology. Compounds such as licarin A, lupeol, and melittin have shown promising anti-inflammatory and antiangiogenic properties in experimental models, with favorable […]

ABSTRACT Objective: To investigate, using current data, the importance of the eye test in the early diagnosis of retinoblastoma. Methods: This is an integrative literature review, with searches in databases of publications between the years 2000 and 2024, in Portuguese, English and Spanish, and 17 articles were selected for the research. Results: The main advantages of the eye test are its simplicity of performance, portability of the equipment, and non-invasive and rapid nature. The absence of the pupillary reflex or […]

ABSTRACT Our objective was to evaluate and describe the techniques and outcomes of limbal stem cell transplantation in patients with limbal stem cell deficiency after chemical burn of the ocular surface. We performed this literature review using the PubMed® (MEDLINE), Cochrane and Embase (Elsevier) databases. Of the 313 studies found, 276 were removed as duplicates and ineligible based on the inclusion and exclusion criteria; 17 articles remained after full reading, classified according to the criteria of interest, and 1 article […]

ABSTRACT This study reviews the scientific literature on global opinion surveys to analyze the perceptions and practices of eye care professionals in myopia management and prescription trends. Fourteen studies published between 2018 and 2024 were included, using search terms such as Myopia, Surveys, Attitudes, Opinions, Myopia Control, Management, and Progression. The results indicate a growing concern about the increasing prevalence of myopia, reflected in the broader adoption of evidence-based strategies, particularly behavioral interventions for progression control. However, a significant number […]

ABSTRACT Background: Trabeculectomy is a common surgical technique performed when clinical treatments are not enough to control glaucoma. Prolonged use of eye drops to control intraocular pressure (IOP) can lead to ocular surface disease, negatively affecting postoperative results. Objective: This article aimed to analyze the current literature on the effects of preoperative preparation for trabeculectomy with topical corticosteroids on surgical outcome and postoperative intervention. Methods: A systematic review that followed PRISMA guidelines was performed, and articles were searched at PubMed, […]

ABSTRACT Background: There is a debate regarding the differences in intraocular pressure values between different types of dispersive ophthalmic viscosurgical devices in patients after phacoemulsification for cataracts. Objectives: We aim to evaluate the differences between hydroxypropyl methylcellulose and sodium hyaluronate alone or combined with chondroitin sulfate as ophthalmic viscosurgical devices after phacoemulsification in selected patients related to intraocular pressure. Methods: We conducted a systematic review and meta-analysis of randomized clinical trial data comparing only dispersive hydroxypropyl methylcellulose with sodium hyaluronate […]

ABSTRACT This update article aims to discuss gene therapies under study for retinal diseases, mainly among the different inherited retinal dystrophies. Inherited retinal dystrophies are considered rare diseases, some are ultra-rare. The use of Luxturna, which was approved by the FDA in 2017 and by Anvisa in 2020, changed the natural history of the retinopathy associated with biallelic variants in RPE65 gene and was a major milestone in ophthalmology. There are still many challenges for this new therapeutic modality, which […]

ABSTRACT Diabetic retinopathy and diabetic macular edema are leading causes of preventable vision loss, with a rising global impact due to the increasing prevalence of diabetes mellitus. This review article synthesizes current evidence regarding the management of diabetic retinopathy, addressing pathophysiological mechanisms and evidence-based therapeutic recommendations from major clinical trials. Key topics include screening strategies, updated classification systems, systemic control, and ocular therapies such as anti-vascular endothelial growth factor (anti-VEGF) agents, corticosteroids, laser photocoagulation, and vitrectomy. Emerging medication approaches, sustained-release […]