Original Articles February 01, 2008 February 01, 2008

Central corneal thickness and central corneal endothelial cells density after trabeculectomy with and without mitomycin C

DOI: 10.1590/S0034-72802008000100005

PURPOSE: To assess comparatively the central corneal thickness (CCT), the central corneal endothelial cells density (CECD) and mean area (CECAA), of patients who underwent trabeculectomy (Trab) with or without mytomicyn C (MMC). METHODS: Prospective study. Twenty-nine eyes were divided in two groups: Trab with or without MMC. Ultrasonic pachymetry and non-contact specular microscopy were performed pre-operatively and three and six months after Trab. The mean value of the CECD and the low value of the CCT were used. RESULTS: In the group of Trab with MMC, the variations of the CCT, CECD and CECAA values were, respectively: – 11.9±25.7 µm, – 169.5±145.3 cells/mm² and 42.5±33.4 µm² (three months); – 7.5±28.1 µm, – 220.6±200.2 cells/mm² and 31.5±65.3 µm² (six months). In the group of Trab without MMC, the variations of the CCT, CECD and CECAA values were, respectively: – 13.9±16.7 µm, – 200.8±155.4 cells/mm² and 34.6±52.4 µm² (three months); – 10.2±15.6 µm, – 277.6±195.7 cells/mm² and 34.3±41.0 µm² (six months). CONCLUSION: After six months of follow-up,there was no difference in the variations of CCT, CECD and CECAA when Trab with MMC was compared with Trab without MMC.