Case Report April 01, 2026 April 01, 2026

Primary conjunctival amyloidosis mimicking Parinaud’s syndrome

DOI: 10.37039/1982.8551.20260028

ABSTRACT

Amyloidosis is characterized by the extracellular deposition of amyloid protein fibrils in tissues, including the conjunctiva, due to their insolubility in proteolytic enzymes. Conjunctival amyloidosis, particularly involving the eyelid conjunctiva, is a rare clinical entity. We report the case of a 60-year-old Caucasian female who presented with a unilateral lesion in the inferior bulbar conjunctiva, extending to the entire inferior tarsal region and fornix. The lesion appeared as an extensive, elevated, pinkish-yellowish nodular mass with poorly defined borders. An incisional biopsy was performed, and histopathology confirmed the diagnosis of conjunctival amyloidosis. Management of conjunctival amyloidosis depends on the extent of local involvement and the patient’s systemic condition, ranging from symptomatic treatment, such as the use of lubricants, to surgical excision. In most cases, complete excision is not feasible due to extensive lesion infiltration, as seen in our case, where a conservative approach was adopted.