ABSTRACT Objective: To critically review current therapeutic strategies for Sjögren’s syndrome (SS), emphasizing ocular and respiratory manifestations, and highlighting innovative interventions with clinical applicability. Methods: This is an integrative literature review based on the PICO strategy. A systematic search was conducted in the VHL, SciELO, MEDLINE, and LILACS databases, covering publications from 2020 to 2025. Controlled descriptors and free terms related to “Sjögren’s Syndrome,” “Interdisciplinary Approach,” and “Ocular Manifestations” were used to identify relevant scientific evidence on the multidisciplinary management […]