ABSTRACT This update article aims to discuss gene therapies under study for retinal diseases, mainly among the different inherited retinal dystrophies. Inherited retinal dystrophies are considered rare diseases, some are ultra-rare. The use of Luxturna, which was approved by the FDA in 2017 and by Anvisa in 2020, changed the natural history of the retinopathy associated with biallelic variants in RPE65 gene and was a major milestone in ophthalmology. There are still many challenges for this new therapeutic modality, which […]

ABSTRACT Retinal vasoproliferative tumor is a rare disease associated with several sight-threatening complications. The optimum management of retinal vasoproliferative tumor is unknown and the need of surgery arises when there is diagnostic uncertainty or sight-threatening complications, such as 23G pars plana vitrectomy, perfluorooctane retinal flattening, fluid drainage through a peripheral retinotomy, fluid-air exchange, laser photocoagulation of the retinal vasoproliferative tumor, and 12.5% C3F8 tamponade. We described two cases of retinal vasoproliferative tumor with exudative retinal detachment threatening the macula, treated […]