ABSTRACT Objective: Embryonic exposure to valproic acid is a widely used model for the study of neurodevelopmental disorders such as autism spectrum disorders. In zebrafish, early exposure to valproic acid results in the major behavioral, neurological, and genetic phenotypes of this disorder. Autism spectrum disorders have several associated symptoms, such as changes in sensory processing, sleep problems, and hyper- or hyposensitivity to light. This work investigates the hypothesis of changes at the retinal level due to embryonic exposure to valproic […]

ABSTRACT Objective: To delineate the epidemiological profile of patients with rhegmatogenous retinal detachment at a reference hospital in the state of Santa Catarina, Brazil. Methods: A retrospective observational study of 381 eyes, with secondary data collection and a quali-quantitative approach during one year. Patient characteristics and details of the provided care were collected. Results: The majority of cases involved males (70.34%), aged between 50 and 69 years old, referred from external medical services. The time for ophthalmic care ranged from […]

ABSTRACT Cavernous sinus thrombosis is a rare, capricious condition, associated with the extension of infectious processes, which may originate from the middle third of the face, such as sinusitis that affects the paranasal sinuses of the face. Namely, the primary sites of infection are commonly the face, orbits and ethmoid, and sphenoid sinuses. The typical clinical presentation includes fever and periorbital edema followed by headache, ptosis and extraocular muscle paralysis. The diagnosis is eminently clinical and difficult to make. It […]

ABSTRACT Objective: To present a novel, low-cost, and accessible methodology for capturing high-quality stereoscopic images and streaming it in real time to a standard three-dimensional television in a surgical setting, utilizing readily available smartphones. Methods: Two smartphones were attached to each eyepiece of the surgical microscope using a custom-made adapter. The smartphones recorded the surgical procedure and streamed the video via HDMI cables to a dual-input multi-viewer, which combined the feeds into a single image displayed on a conventional 3D […]

ABSTRACT Objective: To characterize the effectiveness of anti-vascular endothelial growth factor drugs in exudative age-related macular degeneration. Methods: Retrospective longitudinal study of 54 patients with age-related macular degeneration receiving bevacizumab or aflibercept. Demographic data, visual acuity, and central retinal thickness measurements were collected. Improvement/stability of visual acuity and reduction in retinal thickness configured satisfactory responses. Results: Among the 60 eyes studied, there was no difference (p = 0.262) in satisfactory response when using bevacizumab (48.5%) or aflibercept (63.0%). Snellen’s visual […]

ABSTRACT Retinal detachment related to retinopathy of prematurity is a surgical challenge, and vitrectomy can directly release transvitreal traction resulting from fibrous proliferation. The presence of iatrogenic breaks is a poor prognostic factor and has been considered a dismal prognosis. We report a case of premature female baby that underwent a 3-port 23-Gauge pars plana vitrectomy for stage 4A retinopathy of prematurity, with intraoperative progressive rhegmatogenous detachment complication. Lensectomy, extensive membrane dissection and vitreous shaving, followed by a posterior retinotomy, […]

ABSTRACT Objective To evaluate the indirect ophthalmoscopy performed in ophthalmologic consultations, analyzing the prevalence of the study and comparing them with the reason for the consultation. Methods Cross-sectional study, with data found during the indirect ophthalmoscopy exam of inpatients or in emergency room care. The data analyzed for each patient was sex, the requested medical age, the reason for the consultation and the funduscopic examination findings. Results One hundred and four patients were evaluated and 43.27% of patients with a […]

ABSTRACT Objective Vascular findings in preeclampsia are usually attributed to increased vascular tone. Recently, however, important studies have improved the understanding of the main pathophysiological events in this condition, especially vascular brain remodeling, impaired autoregulation, and damage of the blood-brain barrier, which are well recognized features of cerebral overperfusion. Methods In this study, the association between choriocapillaris ischemia with ophthalmic artery blood flow parameters on orbital Doppler ultrasound is reported for the first time using multivariate logistic models. Multivariate logistic […]