Rev Bras Oftalmol.2012;71(3):194-198

Importance of genetic polymorphisms in the response to age-related macular degeneration treatment

Carlos Eduardo dos Reis
Veloso
, Luciana Negrão Frota de
Almeida
, Luiz Armando De
Marco
, Raul Nunes Galvarro
Vianna
, Márcio Bittar
Nehemy

DOI: 10.1590/S0034-72802012000300011

Age-related macular degeneration (AMD) is a degenerative disorder that affects the central retina and involves the Bruch’s membrane, the retinal pigment epithelium and the photoreceptors. Recent studies have shown that polymorphisms of the CFH, LOC387715 and VEGF genes are associated with AMD. Herein, we review the literature to analyze the association between the main genetic polymorphisms and the response to the existing therapeutic modalities. Patients with CFH high-risk alleles show a poorer response to preventive treatment of AMD with antioxidants and zinc.The association between genetic polymorphisms and response to photodynamic therapy and antiangiogenic drugs, however, is controversial until now.

Importance of genetic polymorphisms in the response to age-related macular degeneration treatment

Keywords: ; ; ;

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