Case Report September 11, 2025 September 11, 2025

Ocular Whipple’s disease: a very rare clinical presentation

DOI: 10.37039/1982.8551.20250061

ABSTRACT

Whipple’s disease is a rare multisystemic condition caused by Tropheryma whipplei. In its early stages, it typically presents with joint symptoms, progressing in later stages primarily to digestive disorders. Although ocular involvement is uncommon, it may be one of the first manifestations of the disease, presenting a diagnostic challenge. Polymerase chain reaction testing or periodic acid Schiff staining of affected tissues can assist in early diagnosis when symptoms are non-specific, which is crucial for initiating early antibiotic therapy and thus modifying the progressive course of the disease, preventing irreversible ocular damage.