ABSTRACT An 81-year-old male patient with systemic hypertension, diabetes mellitus, and dyslipidemia presented with sudden visual acuity loss in the right eye (RE) due to a branch retinal artery occlusion (BRAO) associated with macular edema. Despite treatment with intravitreal bevacizumab, the patient developed persistent inner retinal ischemia, evidenced by optical coherence tomography (OCT) findings of retinal inner plexiform layer (RIPL) alterations. Years later, he suffered an ischemic stroke, highlighting the association between retinal ischemic changes and systemic vascular risk. This […]

ABSTRACT Optical coherence tomography is an imaging technique widely used in the diagnosis and monitoring of patients with age-related macular degeneration, being crucial for differentiating between the dry and exudative forms of the disease. The recognition and interpretation of various age-related macular degeneration biomarkers in optical coherence tomography play a key role in identifying signs of activity, chronicity, disease progression, and, most importantly, in monitoring the response to treatment and prognosis. Understanding the biomarkers enables the ophthalmologist to optimize their […]

ABSTRACT It is part of the omic sciences to search for an understanding of how the cellular system of organisms works as well as studying their biological changes. As part of the omic sciences, we can highlight the genomics whose function is the study of genes, the transcriptomics that studies the changes in the transcripts, the proteomics responsible for understanding the changes that occur in proteins, and the metabolomics that studies all the metabolic changes that occur in a certain […]

ABSTRACT The objective of this article was to review the disorganization of inner retinal layers as a biomarker in diabetic macular edema. A systematic search was conducted in PubMed®/MEDLINE®, Cochrane and Embase until August 2021. The keywords used were: “disorganization of inner retinal layers (DRIL)”, “diabetic macular edema (DME)” and “biomarkers”. No restrictions were imposed on the types of study to be included. The studies selected for eligibility were those that included the diagnosis of diabetic macular edema (center involved, […]

ABSTRACT Age-related macular degeneration is the most important cause of irreversible vision loss in the elderly and has been considered a severe public health problem. Current treatments have only been successful in delaying the loss of central vision. Due to increased life expectancy, governments and researchers have been challenged to seek more efficient and successful treatments for age-related macular degeneration. Considering its relevance for public health and the need of further research, this article aims to address age-related macular degeneration […]