Rev Bras Oftalmol.2025;84:e0060
Clinical use of topical hyaluronan for promoting corneal wound healing: a systematic review
DOI: 10.37039/1982.8551.20250060
ABSTRACT
Introduction:
Hyaluronan/hyaluronic acid based therapies are commonly used for treating corneal injuries in the clinic; however, there is a lack of consensus on whether hyaluronic acid promotes corneal wound healing. This systematic review critically evaluated peer-reviewed publications describing the clinical use of topical hyaluronic acid for treating corneal injuries.
Methods:
Unfiltered searches were conducted to identify peer-reviewed publications describing the clinical use of topical hyaluronic acid for treating various forms of corneal injuries using PubMed® and the University of Houston Library online databases. Citations were screened and data extracted according to the PRISMA checklist.
Results:
A total of 16 articles using topical hyaluronic acid administration for treating corneal injuries were included. The concentration of hyaluronic acid used ranged from 0.1% to 2%, and the frequency of administration ranged from a single dose to 24 times daily. Overall, the studies identified that hyaluronic acid successfully promotes corneal wound healing, with no reports of any adverse effects.
Conclusions:
The available literature shows that hyaluronic acid promotes corneal wound healing, with no reported adverse effects. There is a lack of consensus on the optimal dosage of hyaluronic acid that should be used for treating corneal wounds in the clinic.
