Dear Editor, We appreciate your thoughtful review of our recently published article. We fully agree that the ideal way to evaluate the potential of oral riboflavin combined with sun exposure would be through a prospective, controlled, large-scale study involving patients with documented progressive keratoconus. Only then would it be possible to unequivocally distinguish the effect of the intervention from natural variability, spontaneous stability, or co-interventions. […]

STUDY DESIGN LIMITATIONS The authors report a retrospective, uncontrolled, multicenter series of 53 patients, with attrition to 42 patients after only 6 months. The absence of a control group or blinding means that natural variability, regression to the mean, or periods of spontaneous stability cannot be excluded as explanations for their findings. The authors acknowledge that “the absence of a control group and blinding, as well as the relatively small number of individuals followed, can be mentioned”. Furthermore, the inclusion […]

INTRODUCTION The aging of the world population has been a reality since the 19th century. Currently, this trend is becoming more pronounced in less developed countries, particularly after the mid-20th century. It has been observed that poorer countries experience a decline in fertility and birth rates, along with an increase in life expectancy and quality of life among their populations.(,) Age-related changes in binocular vision and the prevalence of visual disturbances in the elderly receive little attention. Only a few […]

ABSTRACT Non-infectious uveitis is a major cause of visual loss, particularly among working-age adults. It is an intraocular inflammatory condition mediated by autoreactive T lymphocytes, and its severe forms may require therapies beyond corticosteroids. This article reviews recent advances in the treatment of the disease, emphasizing natural compounds and innovative ocular drug delivery systems, particularly those based on pharmaceutical nanotechnology. Compounds such as licarin A, lupeol, and melittin have shown promising anti-inflammatory and antiangiogenic properties in experimental models, with favorable […]

ABSTRACT This article is aimed at presenting the clinical features and management of two distinct subtypes of Iridocorneal Endothelial Syndrome (ICE), highlighting the importance of differential diagnosis and individualized treatment. It shows two case reports of female patients with progressive visual loss. Ophthalmologic examination was performed, including biomicroscopy, gonioscopy, and specular microscopy. Treatment was defined according to clinical need. The first patient, diagnosed with Cogan-Reese Syndrome, presented with pigmented nodules on the iris, uveal ectropion, and posterior synechiae, being treated […]

ABSTRACT Objective: To describe the clinical features and multidisciplinary management of paralytic lagophthalmos secondary to peripheral facial palsy, focusing on ocular complications. Methods: A cross-sectional, observational, and retrospective analysis was conducted on five patients treated at an ophthalmologic emergency service in Curitiba, Brazil. Results: All patients developed keratitis associated with lagophthalmos, confirming the correlation between these conditions. Treatment included ocular lubrication and corneal reepithelialization, but nocturnal eye occlusion was prescribed in only some cases. Referrals varied with symptom duration: acute […]

ABSTRACT Lamb-Shaffer syndrome (LAMSHF) is a rare condition characterized by neurodevelopmental disorders caused by haploinsufficiency of the SOX5 gene on chromosome 12p12. Clinically, it manifests itself with growth retardation, global neurodevelopmental delay, speech delay, dysmorphic facial features, and musculoskeletal, cardiac, and genitourinary abnormalities. Although frequent, the ophthalmological presentations of this syndrome are not well established in the literature. In this study, we aim to report a new case of this rare condition, highlighting the ophthalmological aspects of its condition.

ABSTRACT Objective: To investigate, using current data, the importance of the eye test in the early diagnosis of retinoblastoma. Methods: This is an integrative literature review, with searches in databases of publications between the years 2000 and 2024, in Portuguese, English and Spanish, and 17 articles were selected for the research. Results: The main advantages of the eye test are its simplicity of performance, portability of the equipment, and non-invasive and rapid nature. The absence of the pupillary reflex or […]