Review Article July 22, 2026 July 22, 2026

Best practices in the administration of intravitreal injections: a Review

DOI: 10.37039/1982.8551.20260068

ABSTRACT

This study aimed to identify and analyze the most recent scientific evidence on best practices for the administration of intravitreal injections, with particular focus on the setting (medical office versus operating room), same-day bilateral administration, and strategies to prevent complications. A literature review was conducted across Medline Complete, Scopus, Web of Science, and Google Scholar databases (2015–2025), using three distinct search strategies. Studies addressing guidelines and protocols, administration setting, and bilateral procedures were included. Data selection and analysis were supported by Rayyan and NVivo software. Fourteen studies met the inclusion criteria. Findings suggest that, when aseptic practices are strictly followed, including mask use and restricted conversation, 5% povidone-iodine disinfection at the puncture site for 30 seconds, and glove use, both office-based administration and bilateral injections are safe. The standardization of protocols emerged as a key factor in preventing complications.