ABSTRACT Objective: To evaluate the therapeutic response to brolucizumab in eyes with chronic neovascular age-related macular degeneration (nAMD) refractory to prior anti-angiogenic treatments. Methods: This prospective observational study included patients with chronic nAMD who maintained exudative neovascularization after at least three injections of ranibizumab and/or aflibercept without previous episodes of uveitis or vasculitis. Participants received one to three intravitreal injections of brolucizumab. Best-corrected visual acuity (BCVA) was assessed before and 4 weeks after each injection, along with analysis of fluid […]

ABSTRACT This study aimed to identify and analyze the most recent scientific evidence on best practices for the administration of intravitreal injections, with particular focus on the setting (medical office versus operating room), same-day bilateral administration, and strategies to prevent complications. A literature review was conducted across Medline Complete, Scopus, Web of Science, and Google Scholar databases (2015–2025), using three distinct search strategies. Studies addressing guidelines and protocols, administration setting, and bilateral procedures were included. Data selection and analysis were […]

ABSTRACT Objective: To determine the evolution of retinopathy of prematurity in patients treated with intravitreal antiangiogenics in the retina private practice. Methods: A retrospective descriptive observational case series study was conducted. The study was non-experimental and non-probabilistic. Based on a population of 61 newborns, with a 99% confidence interval and a margin of error of 1%, the sample would be 61 newborns. The data from Google Sheets was transferred to CVS and then the Statistical Package for the Package Power […]

ABSTRACT Acute corneal hydrops is an ophthalmologic emergency resulting from rupture of Descemet’s membrane with entry of aqueous humor into the corneal stroma. Patients typically present with ocular pain, blurred vision, photophobia, and tearing. The main risk factors include trauma due to ocular itching, allergic keratoconjunctivitis, corneal ectasia, and Down syndrome. Although a rare complication, it is most commonly associated with keratoconus. Clinical treatment with eye drops should always be initiated, but in advanced cases, combined surgical intervention may be […]

ABSTRACT We describe a case of Irvine-Gass syndrome and the clinical decompensation of glaucoma after uneventful cataract surgery with resistance to conventional clinical treatment. Drainage tube implantation and intravitreal injection of dexamethasone were performed simultaneously with the resolution of cystoid macular edema and good control of intraocular pressure, which remained consistent after 1 year of follow-up.

ABSTRACT This work aimed to demonstrate the importance of early detection of punctate inner choroidopathy, highlighting the pathophysiology of inflammation and the differential diagnoses among white dot syndromes. Special attention was given to multifocal choroiditis and panuveitis, by demonstrating the peculiar epidemiology in young women, characterizing the typical clinical presentation in ophthalmoscopy, and exploring the advantages and disadvantages of performing the complementary examinations, which are part of the multimodal analysis useful for diagnosis (particularly fluorescein angiography, optical coherence tomography, and […]

Abstract The purpose is to report a case of laser pointer-induced maculopathy and to describe its characteristics using spectral-domain optical coherence tomography (SD-OCT), further the outcome of treatment with intravitreal injections. A 35-year-old man presented with a 6-day history of central vision loss in his right eye (RE) after an accidental laser pointer discharge (wavelength of 532 nm). He underwent a full ophthalmologic examination, including SD-OCT, which suggested the presence of subfoveal choroidal neovascularization (CNV). This was not confirmed due […]

Purpose: To propose a predictive model to aid in the decision to perform the intravitreal anti-VEGF injection, based on the risk factors quantification and hierarchy presented by diabetic patients. Methods: It is a cross-sectional, observational and inferential study carried out in three institutions in Paraíba from July 2015 to September 2016. The logistic regression model was used to obtain the predictive model and data were analyzed in R(r) software. Results: Eighty patients with type 1 or 2 diabetes, over 18 […]