ABSTRACT Non-infectious uveitis is a major cause of visual loss, particularly among working-age adults. It is an intraocular inflammatory condition mediated by autoreactive T lymphocytes, and its severe forms may require therapies beyond corticosteroids. This article reviews recent advances in the treatment of the disease, emphasizing natural compounds and innovative ocular drug delivery systems, particularly those based on pharmaceutical nanotechnology. Compounds such as licarin A, lupeol, and melittin have shown promising anti-inflammatory and antiangiogenic properties in experimental models, with favorable […]

ABSTRACT This article is aimed at presenting the clinical features and management of two distinct subtypes of Iridocorneal Endothelial Syndrome (ICE), highlighting the importance of differential diagnosis and individualized treatment. It shows two case reports of female patients with progressive visual loss. Ophthalmologic examination was performed, including biomicroscopy, gonioscopy, and specular microscopy. Treatment was defined according to clinical need. The first patient, diagnosed with Cogan-Reese Syndrome, presented with pigmented nodules on the iris, uveal ectropion, and posterior synechiae, being treated […]

ABSTRACT Objective: To describe the clinical features and multidisciplinary management of paralytic lagophthalmos secondary to peripheral facial palsy, focusing on ocular complications. Methods: A cross-sectional, observational, and retrospective analysis was conducted on five patients treated at an ophthalmologic emergency service in Curitiba, Brazil. Results: All patients developed keratitis associated with lagophthalmos, confirming the correlation between these conditions. Treatment included ocular lubrication and corneal reepithelialization, but nocturnal eye occlusion was prescribed in only some cases. Referrals varied with symptom duration: acute […]

ABSTRACT Lamb-Shaffer syndrome (LAMSHF) is a rare condition characterized by neurodevelopmental disorders caused by haploinsufficiency of the SOX5 gene on chromosome 12p12. Clinically, it manifests itself with growth retardation, global neurodevelopmental delay, speech delay, dysmorphic facial features, and musculoskeletal, cardiac, and genitourinary abnormalities. Although frequent, the ophthalmological presentations of this syndrome are not well established in the literature. In this study, we aim to report a new case of this rare condition, highlighting the ophthalmological aspects of its condition.

ABSTRACT Objective: To investigate, using current data, the importance of the eye test in the early diagnosis of retinoblastoma. Methods: This is an integrative literature review, with searches in databases of publications between the years 2000 and 2024, in Portuguese, English and Spanish, and 17 articles were selected for the research. Results: The main advantages of the eye test are its simplicity of performance, portability of the equipment, and non-invasive and rapid nature. The absence of the pupillary reflex or […]

ABSTRACT Objective: To evaluate the epidemiological and clinical profiles, outcomes, and follow-up visits of patients treated in the emergency department of a reference hospital in Paraná, Brazil. Methods: This observational, cross-sectional, and retrospective study analyzed medical records from the emergency department of a reference ophthalmology hospital in Curitiba, Paraná, from December 21, 2021 to March 20, 2022. Results: A total of 8,072 medical records were examined, of which 6,565 were new complaints, 620 were follow-up visits, and 887 were incomplete […]

ABSTRACT Objective: This study aimed to validate the psychometric properties, feasibility, and clinical utility of the Tumbling-Hand test. Methods: The validation process involved two phases. In neurotypical participants, VA thresholds of the Tumbling-Hand test were compared with the printed Tumbling E test, with repeatability assessed using intraclass correlation coefficients (ICCs) and Bland-Altman analysis. In neurodivergent participants, the feasibility and success rates of the Tumbling-Hand test were evaluated against the Tumbling E and Landolt C tests. Statistical analyses, including McNamar’s and […]

ABSTRACT Objective: To assess whether the anteroposterior diameter growth curve in Brazilian children aligns with the Caucasian-European standard used as a reference in Brazil. To evaluate the feasibility of using non-cycloplegic refractometric measurements from an autorefractor based on the anteroposterior diameter for medical prescription. Methods: A prospective, cross-sectional pilot study was conducted with children receiving care through the Brazilian Unified Health System at the Hospital de Olhos do Paraná. Examinations included visual screening, anamnesis, cycloplegic refraction, fundoscopy, measurement of the […]